2746405-41-2
2746405-41-2
Chemical Structure
VU6035406
- CAS No.: 2746405-41-2
- Formula:C15H16ClN5O3S
- Molecular Weight:381.84
InChIKey: URAUBDCJGRESTK-UHFFFAOYSA-N
SMILES: O=S(C1=CN=C(C)O1)(N2CCC(CC2)C3=CN4N=CN=C4C=C3Cl)=O
Biological Activity: VU6035406 is a functionally selective mAChR inhibitor, with mAChR IC50 values of 21 nM, 51 nM and 47 nM against human, rat and mouse targets, respectively. VU6035406 does not act as a P-glycoprotein substrate. VU6035406 shows extremely low inhibitory activity against cytochrome P450 1A2, 2C9, 2D6 and 3A4. VU6035406 can be used in the research of neurological and psychiatric disorders[1].
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VU6035406 | VU6035406 is a functionally selective mAChR inhibitor, with mAChR IC50 values of 21 nM, 51 nM and 47 nM against human, rat and mouse targets, respectively. VU6035406 does not act as a P-glycoprotein substrate. VU6035406 shows extremely low inhibitory activity against cytochrome P450 1A2, 2C9, 2D6 and 3A4. VU6035406 can be used in the research of neurological and psychiatric disorders. | |||||||||||||||||||||
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VU6036864 | VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC50=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%). | |||||||||||||||||||||
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References
