2748239-18-9
Chemical Structure
MS31 trihydrochloride
- CAS No.: 2748239-18-9
- Formula:C20H30Cl3N3O2
- Molecular Weight:450.83
IUPAC Name: (5-(3-(isoindolin-2-yl)propoxy)-4-methoxy-1,3-phenylene)dimethanamine trihydrochloride
InChIKey: ACLRXRSPMJPOKN-UHFFFAOYSA-N
SMILES: NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1.[H]Cl.[H]Cl.[H]Cl
Biological Activity: MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MS31 trihydrochloride | 98.0% | MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
