MS31 trihydrochloride
Based on 3 publication(s) in Google Scholar
MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells.
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- Pureté: 98.0%
- CAS No.: 2748239-18-9
- Formule: C20H30Cl3N3O2
- Masse moléculaire:450.83
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MS31 trihydrochloride
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Activité biologique
Description
IC50 & Target
IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]
Kd: 91 nM (SPIN1)[1]
In Vitro
MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 trihydrochloride selectively binds tudor domain II of SPIN1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2748239-18-9
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Appearance Solid
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Masse moléculaire 450.83
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Formule C20H30Cl3N3O2
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Color White to off-white
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SMILES
NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1.[H]Cl.[H]Cl.[H]Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks. [Abstract]2025 Jun;27(6):992-1005. PMID: 40447771 -
Adv Sci (Weinh)
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins. [Abstract]2025 Nov 29:e17751. PMID: 41316889 -
Nat Struct Mol Biol
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1. [Abstract]2025 Apr 17. PMID: 40247146
Solvant et solubilité
In Vitro:
DMSO : 62.5 mg/mL (138.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2181 mL | 11.0907 mL | 22.1813 mL | 55.4533 mL |
| 5 mM | 0.4436 mL | 2.2181 mL | 4.4363 mL | 11.0907 mL | |
| 10 mM | 0.2218 mL | 1.1091 mL | 2.2181 mL | 5.5453 mL | |
| 15 mM | 0.1479 mL | 0.7394 mL | 1.4788 mL | 3.6969 mL | |
| 20 mM | 0.1109 mL | 0.5545 mL | 1.1091 mL | 2.7727 mL | |
| 25 mM | 0.0887 mL | 0.4436 mL | 0.8873 mL | 2.2181 mL | |
| 30 mM | 0.0739 mL | 0.3697 mL | 0.7394 mL | 1.8484 mL | |
| 40 mM | 0.0555 mL | 0.2773 mL | 0.5545 mL | 1.3863 mL | |
| 50 mM | 0.0444 mL | 0.2218 mL | 0.4436 mL | 1.1091 mL | |
| 60 mM | 0.0370 mL | 0.1848 mL | 0.3697 mL | 0.9242 mL | |
| 80 mM | 0.0277 mL | 0.1386 mL | 0.2773 mL | 0.6932 mL | |
| 100 mM | 0.0222 mL | 0.1109 mL | 0.2218 mL | 0.5545 mL |
MS31 trihydrochloride Related Classifications
HY-125837A Related Classifications
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