2. Epigenetics
  3. Epigenetic Reader Domain
  4. MS31 trihydrochloride

MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells.

For research use only. We do not sell to patients.

MS31 trihydrochloride Chemical Structure

MS31 trihydrochloride Chemical Structure

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 495 In-stock
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 650 In-stock
50 mg USD 1650 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of MS31 trihydrochloride:

MS31 trihydrochloride Related Antibodies

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Description

MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1].

IC50 & Target

IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1]
Kd: 91 nM (SPIN1)[1]
In Vitro

MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 trihydrochloride selectively binds tudor domain II of SPIN1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS31 trihydrochloride Related Antibodies
Molecular Weight

450.83

Formula

C20H30Cl3N3O2
Appearance

Solid

Color

White to off-white

SMILES

NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (138.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2181 mL 11.0907 mL 22.1813 mL
5 mM 0.4436 mL 2.2181 mL 4.4363 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2181 mL 11.0907 mL 22.1813 mL 55.4533 mL
5 mM 0.4436 mL 2.2181 mL 4.4363 mL 11.0907 mL
10 mM 0.2218 mL 1.1091 mL 2.2181 mL 5.5453 mL
15 mM 0.1479 mL 0.7394 mL 1.4788 mL 3.6969 mL
20 mM 0.1109 mL 0.5545 mL 1.1091 mL 2.7727 mL
25 mM 0.0887 mL 0.4436 mL 0.8873 mL 2.2181 mL
30 mM 0.0739 mL 0.3697 mL 0.7394 mL 1.8484 mL
40 mM 0.0555 mL 0.2773 mL 0.5545 mL 1.3863 mL
50 mM 0.0444 mL 0.2218 mL 0.4436 mL 1.1091 mL
60 mM 0.0370 mL 0.1848 mL 0.3697 mL 0.9242 mL
80 mM 0.0277 mL 0.1386 mL 0.2773 mL 0.6932 mL
100 mM 0.0222 mL 0.1109 mL 0.2218 mL 0.5545 mL
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MS31 trihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS31 trihydrochlorideEpigenetic Reader Domainmethyllysinereaderproteintudordomainprotein-proteininteractionsH3K4me3Inhibitorinhibitorinhibit

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