2758171-54-7
2758171-54-7
Chemical Structure
DW34
- CAS No.: 2758171-54-7
- Formula:C25H34N6O
- Molecular Weight:434.58
InChIKey: PIKWYDHWUKSWAQ-UHFFFAOYSA-N
SMILES: CC1=C(N(C2CCN(CC2)CCN(C)C)N=N1)C3=CC=CC(OC4=CC(C)=CC(C)=C4)=N3
Biological Activity: DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC50 = 0.16 μM) with low nanomolar EC50 values of 0.14 μM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis[1].
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DW34 | DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC50 = 0.16 μM) with low nanomolar EC50 values of 0.14 μM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis. | |||||||||||||||||||||
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References
Keywords
