2758802-17-2
2758802-17-2
Chemical Structure
HSD17B13-IN-19
- CAS No.: 2758802-17-2
- Formula:C23H23FN2O4S
- Molecular Weight:442.50
InChIKey: HJBDUAGEXDPCFC-UHFFFAOYSA-N
SMILES: O=C(NCCC1=C(OC)C=CC=C1)C2=C(NC(C3=CC=C(O)C(F)=C3)=O)SC(C)=C2C
Biological Activity: HSD17B13-IN-19 (compound 16) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-19? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-19 | HSD17B13-IN-19 (compound 16) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-19? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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