2760195-67-1
2760195-67-1
Chemical Structure
SYHA1815
- CAS No.: 2760195-67-1
- Formula:C27H26ClF4N5O
- Molecular Weight:547.97
InChIKey: SWMFIGMUMWFQHQ-UHFFFAOYSA-N
SMILES: CN(CC1)CCN1CC2=C(C(F)(F)F)C=C(NC(C3=CC(F)=CC(C#CC4=CC=CN=C4N)=C3)=O)C=C2.Cl
Biological Activity: SYHA1815 is an orally active RET inhibitor (IC50=0.9 nmol/L) with antitumor activity. SYHA1815 is more selective for RET than KDR (IC50=15.9 nmol/L). SYHA1815 arrests the G1 cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc[1].
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SYHA1815 | SYHA1815 is an orally active RET inhibitor (IC50=0.9 nmol/L) with antitumor activity. SYHA1815 is more selective for RET than KDR (IC50=15.9 nmol/L). SYHA1815 arrests the G1 cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc. | |||||||||||||||||||||
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References
Keywords
