2760807-99-4
Chemical Structure
Pseudouridimycin TFA
Synonym(s): PUM TFA
- CAS No.: 2760807-99-4
- Formula:C19H27F3N8O11
- Molecular Weight:600.46
InChIKey: QVDKLWNBWGUBHE-XFMFGANJSA-N
SMILES: O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O.OC(C(F)(F)F)=O
Biological Activity: Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].
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Pseudouridimycin TFA | Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis. | |||||||||||||||||||||
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- [1]. Rosenqvist P, et al. Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin. Sci Rep. 2019 Jun 20;9(1):8935. [Content Brief]
- [2]. Kunthavai Pavundurai Chandra, et al. Pseudouridimycin-A Potent Nucleoside Inhibitor of the RNA. ACS Omega. 2023 Feb 13;8(8):7989-8000. [Content Brief]
Keywords
