2763641-30-9
2763641-30-9
Chemical Structure
5-C-phenethyl-DNJ hydrochloride
- CAS No.: 2763641-30-9
- Formula:C14H22ClNO4
- Molecular Weight:303.78
InChIKey: ZMXDULQBDPMPKT-BHARVXRSSA-N
SMILES: OC[C@@]1([C@H]([C@@H]([C@H](CN1)O)O)O)CCC2=CC=CC=C2.Cl
Biological Activity: 5-C-phenethyl-DNJ hydrochloride is an orally active GAA inhibitor/stabilizer. 5-C-phenethyl-DNJ hydrochloride competitively inhibits and stabilizes GAA, with a human IC50 of 0.81 μM and a Ki of 7.6 μM, and improves enzyme maturation and lysosomal delivery. 5-C-phenethyl-DNJ hydrochloride can be used for research on Pompe disease[1].
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5-C-phenethyl-DNJ hydrochloride | 5-C-phenethyl-DNJ hydrochloride is an orally active GAA inhibitor/stabilizer. 5-C-phenethyl-DNJ hydrochloride competitively inhibits and stabilizes GAA, with a human IC50 of 0.81 μM and a Ki of 7.6 μM, and improves enzyme maturation and lysosomal delivery. 5-C-phenethyl-DNJ hydrochloride can be used for research on Pompe disease. | |||||||||||||||||||||
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