2763825-83-6
2763825-83-6
Chemical Structure
CLL1-L1
- CAS No.: 2763825-83-6
- Formula:C36H62N12O13S2
- Molecular Weight:935.08
InChIKey: SNXCOVFATVUAIE-ZARQWVMYSA-N
SMILES: O=C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@H]1C(C)C)=O)=O)=O)=O)=O)=O)[C@@H](N)CSSC[C@@H](C(O)=O)NC1=O
Biological Activity: CLL1-L1 is a peptide ligand targeting CLL1, which binds to CLL1 on leukemia stem cells and enables selective targeting of CLL1-expressing cells. CLL1-L1 can be covalently coated onto telodendrimer nanomicelles to mediate drug delivery to leukemia stem cells. CLL1-L1 is useful for research related to leukemia drug delivery[1][2][3].
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CLL1-L1 | CLL1-L1 is a peptide ligand targeting CLL1, which binds to CLL1 on leukemia stem cells and enables selective targeting of CLL1-expressing cells. CLL1-L1 can be covalently coated onto telodendrimer nanomicelles to mediate drug delivery to leukemia stem cells. CLL1-L1 is useful for research related to leukemia drug delivery. | |||||||||||||||||||||
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References
- [1]. Zhang H, et al. Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells. Nanomedicine : nanotechnology, biology, and medicine. 2012 Oct;8(7):1116-24.
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[2]. Zhang H, et al. Abstract 3488: Targeting ligands and nanotherapeutics against acute myeloid leukemia stem cell. Cancer Research, 2012, 72(8_Supplement): 3488.
- [3]. Visani G, et al. Nanomedicine strategies for hematological malignancies: what is next?. Nanomedicine (London, England). 2014 Oct;9(15):2415-28.
