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Cat. No.: HY-P12362

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CLL1-L1

CLL1-L1 is a peptide ligand targeting CLL1, which binds to CLL1 on leukemia stem cells and enables selective targeting of CLL1-expressing cells. CLL1-L1 can be covalently coated onto telodendrimer nanomicelles to mediate drug delivery to leukemia stem cells. CLL1-L1 is useful for research related to leukemia drug delivery.

For research use only. We do not sell to patients.

CAS No.: 2763825-83-6
Formula: C₃₆H₆₂N₁₂O₁₃S₂
Molecular Weight:935.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

CLL1-L1 Chemical Structure

CAS No.: 2763825-83-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

CLL1-L1 (CDLRSAAVC) binds specifically to cells expressing CLL1, including A549 and K562 cells expressing recombinant CLL1, but not to parental cells or other cell lines^[1].
CLL1-L1-decorated targeting nanomicelles (10-60 minutes) are taken up by A549 cells expressing CLL1-GFP within ten minutes, as evidenced by strong DiI fluorescence^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

CLL1‑L1 can modify the surface of Daunorubicin (HY-13062A)-loaded nanomicelles, and this modification significantly enhances the delivery efficiency of Daunorubicin to CLL1-positive leukemia cells; moreover, the toxicity of these CLL1-L1-targeted nanomicelles in BALB/c mice is approximately one-third that of the parent free compound^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2763825-83-6
Molecular Weight 935.08
Formula C₃₆H₆₂N₁₂O₁₃S₂
Sequence

Cys-Asp-Leu-Arg-Ser-Ala-Ala-Val-Cys (disulfide bridge:Cys1-Cys9)
Sequence Shortening

CDLRSAAVC (disulfide bridge:Cys1-Cys9)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang H, et al. Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells. Nanomedicine : nanotechnology, biology, and medicine. 2012 Oct;8(7):1116-24.

[2]. Zhang H, et al. Abstract 3488: Targeting ligands and nanotherapeutics against acute myeloid leukemia stem cell. Cancer Research, 2012, 72(8_Supplement): 3488.

[3]. Visani G, et al. Nanomedicine strategies for hematological malignancies: what is next?. Nanomedicine (London, England). 2014 Oct;9(15):2415-28.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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