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United States

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製品番号: HY-P12362

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CLL1-L1

CLL1-L1 is a peptide ligand targeting CLL1, which binds to CLL1 on leukemia stem cells and enables selective targeting of CLL1-expressing cells. CLL1-L1 can be covalently coated onto telodendrimer nanomicelles to mediate drug delivery to leukemia stem cells. CLL1-L1 is useful for research related to leukemia drug delivery.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2763825-83-6
分子式: C₃₆H₆₂N₁₂O₁₃S₂
分子量:935.08

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

CLL1-L1 構造式

CAS 番号: 2763825-83-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CLL1-L1 (CDLRSAAVC) binds specifically to cells expressing CLL1, including A549 and K562 cells expressing recombinant CLL1, but not to parental cells or other cell lines^[1].
CLL1-L1-decorated targeting nanomicelles (10-60 minutes) are taken up by A549 cells expressing CLL1-GFP within ten minutes, as evidenced by strong DiI fluorescence^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

CLL1‑L1 can modify the surface of Daunorubicin (HY-13062A)-loaded nanomicelles, and this modification significantly enhances the delivery efficiency of Daunorubicin to CLL1-positive leukemia cells; moreover, the toxicity of these CLL1-L1-targeted nanomicelles in BALB/c mice is approximately one-third that of the parent free compound^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2763825-83-6
分子量 935.08
分子式 C₃₆H₆₂N₁₂O₁₃S₂
配列

Cys-Asp-Leu-Arg-Ser-Ala-Ala-Val-Cys (disulfide bridge:Cys1-Cys9)
シーケンスの短縮

CDLRSAAVC (disulfide bridge:Cys1-Cys9)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhang H, et al. Characterization of high-affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells. Nanomedicine : nanotechnology, biology, and medicine. 2012 Oct;8(7):1116-24.

[2]. Zhang H, et al. Abstract 3488: Targeting ligands and nanotherapeutics against acute myeloid leukemia stem cell. Cancer Research, 2012, 72(8_Supplement): 3488.

[3]. Visani G, et al. Nanomedicine strategies for hematological malignancies: what is next?. Nanomedicine (London, England). 2014 Oct;9(15):2415-28.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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