2765785-88-2
2765785-88-2
Chemical Structure
ATR-IN-14
- CAS. Nr.: 2765785-88-2
- Formula:C20H20FN7O
- Molecular Weight:393.42
IUPAC Name: (R)-4-(5-fluoro-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)-3-methylmorpholine
InChIKey: DWIFLVFTZABWNK-GFCCVEGCSA-N
SMILES: C[C@@H]1COCCN1C2=NC3=C(N=CC(F)=C3C(C4=CC=NN4C)=C2)C5=CC=NN5
Biological Activity: ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].
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ATR-IN-14 | ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM. | |||||||||||||||||||||
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