ATR-IN-14
ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM.
For research use only. We do not sell to patients.
- CAS No.: 2765785-88-2
- Formula: C20H20FN7O
- Molecular Weight:393.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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ATR |
Chemical Information
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CAS No. 2765785-88-2
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Molecular Weight 393.42
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Formula C20H20FN7O
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SMILES
C[C@@H]1COCCN1C2=NC3=C(N=CC(F)=C3C(C4=CC=NN4C)=C2)C5=CC=NN5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)