1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR
  3. ATR-IN-14

ATR-IN-14 

Cat. No.: HY-147566
Handling Instructions

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM.

For research use only. We do not sell to patients.

ATR-IN-14 Chemical Structure

ATR-IN-14 Chemical Structure

CAS No. : 2765785-88-2

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Description

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].

IC50 & Target

ATR

 

Molecular Weight

393.42

Formula

C20H20FN7O

CAS No.
SMILES

C[[email protected]@H]1COCCN1C2=NC3=C(N=CC(F)=C3C(C4=CC=NN4C)=C2)C5=CC=NN5

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Please store the product under the recommended conditions in the Certificate of Analysis.

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ATR-IN-14
Cat. No.:
HY-147566
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