2765823-81-0
2765823-81-0
Chemical Structure
HSP90-IN-28
- CAS 番号: 2765823-81-0
- Formula:C23H21NO2S
- Molecular Weight:375.48
IUPAC Name: (3-((3-ethylphenyl)thio)-4-hydroxyphenyl)(isoindolin-2-yl)methanone
InChIKey: DXJOUWXZUXYSRX-UHFFFAOYSA-N
SMILES: O=C(N1CC2=C(C1)C=CC=C2)C3=CC=C(C(SC4=CC=CC(CC)=C4)=C3)O
Biological Activity: HSP90-IN-28 (compound 12 h) is a potent and selective Hsp90 inhibitor with an IC50 of 0.46 μM for Hsp90α. HSP90-IN-28 exhibits ~48 fold selectivity versus other Hsp90β (IC50 = 22.28 μM)[1].
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HSP90-IN-28 | HSP90-IN-28 (compound 12 h) is a potent and selective Hsp90 inhibitor with an IC50 of 0.46 μM for Hsp90α. HSP90-IN-28 exhibits ~48 fold selectivity versus other Hsp90β (IC50 = 22.28 μM). | |||||||||||||||||||||
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References
Keywords
