2767203-39-2
Chemical Structure
NOTA-WL12
- CAS No.: 2767203-39-2
- Formula:C111H154N26O26S2
- Molecular Weight:2332.70
InChIKey: VOARTUUCYYQFLI-XYLPUYTLSA-N
SMILES: CN1C2=CC=CC=C2C(C[C@H]3C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N4[C@](CCC4)([H])C(N[C@H](C(N[C@H](C(N5[C@](C[C@H](C5)O)([H])C(N[C@H](C(N[C@H](C(N3)=O)CO)=O)CC6=CNC7=CC=CC=C67)=O)=O)CC(C)C)=O)CC8=CN=CN8)=O)=O)CC(N)=O)=O)C)C)=O)CC9=CC=C(C=C9)O)=O)C(NCC(N)=O)=O)=O)CCCNC(NC%10=CC=C(CC(N%11CC(O)=O)CN(CCN(CC%11)CC(O)=O)CC(O)=O)C=C%10)=S)=O)CCCC)C)=O)CCCC)C)=O)=C1
Biological Activity: NOTA-WL12 is a peptide-based imaging probe targeting PD-L1. NOTA-WL12 is a PD-L1 inhibitory peptide derivative and also a NOTA-conjugated WL12 precursor used for 68Ga radiolabeling. The binding of NOTA-WL12 to human and mouse PD-L1 is evaluated by surface plasmon resonance. NOTA-WL12 is predicted by computational docking to interact with PD-L1[1][2][3].
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NOTA-WL12 | NOTA-WL12 is a peptide-based imaging probe targeting PD-L1. NOTA-WL12 is a PD-L1 inhibitory peptide derivative and also a NOTA-conjugated WL12 precursor used for 68Ga radiolabeling. The binding of NOTA-WL12 to human and mouse PD-L1 is evaluated by surface plasmon resonance. NOTA-WL12 is predicted by computational docking to interact with PD-L1. | |||||||||||||||||||||
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References
- [1]. Yang Zhang, et al. PET Imaging of Peptide Probe Al[18F]F-NOTA-PCP1 for Monitoring the Engagement of PD-L1 Antibodies in Tumors. Mol. Pharmaceutics 4 March 2024; 21 (3): 1515-1525.
- [2]. Ferro-Flores G, et al. Synthesis and Evaluation of [18F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu]Lu-DOTA-iPD-L1. Pharmaceutics. 2025 Jul 16;17(7):920. [Content Brief]
- [3]. Li D, et al. Construction of an Iodine-Labeled CS1001 Antibody for Targeting PD-L1 Detection and Comparison with Low-Molecular-Peptide Micro-PET Imaging. Molecular pharmaceutics. 2022 Nov 07;19(11):4382-4389. [Content Brief]
