2769753-10-6
2769753-10-6
Chemical Structure
TAE648
Synonym(s): TL13-87
- CAS No.: 2769753-10-6
- Formula:C23H27ClN6O2S
- Molecular Weight:487.02
InChIKey: JFCFCFUGYYYTQB-UHFFFAOYSA-N
SMILES: ClC(C=N1)=C(NC2=C(S(C(C)C)(=O)=O)C=CC=C2)N=C1NC(C=C3)=CC=C3N4CCNCC4
Biological Activity: TAE648 is a target protein ligand of PROTAC SK-3-91 (HY-137341) (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC[1]. TAE648 decreases monolayer-cultured SKOV3ip1 cell viability[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TAE648 | 99.50% | TAE648 is a target protein ligand of PROTAC SK-3-91 (HY-137341) (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC. TAE648 decreases monolayer-cultured SKOV3ip1 cell viability. | ||||||||||||||||||||
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References
- [1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. [Content Brief]
- [2]. Cha HJ, et al. Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells. Int J Oncol. 2017 Apr;50(4):1279-1288. [Content Brief]
