2770804-58-3
Chemical Structure
Topoisomerase I/II inhibitor 2
- CAS No.: 2770804-58-3
- Formula:C19H16N2O4
- Molecular Weight:336.34
IUPAC Name: 1-(6-([1,3]dioxolo[4,5-h]isoquinolin-7-yl)benzo[d][1,3]dioxol-5-yl)-N-methylmethanamine
InChIKey: RIMCZMJTNGFZNC-UHFFFAOYSA-N
SMILES: CNCC1=CC2=C(OCO2)C=C1C3=CC4=C(C5=C(OCO5)C=C4)C=N3
Biological Activity: Topoisomerase I/II inhibitor 2 (compound 1a) is a potent Topoisomerase inhibitor (IC50= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in researching liver cancer[1].
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Topoisomerase I/II inhibitor 2 | Topoisomerase I/II inhibitor 2 (compound 1a) is a potent Topoisomerase inhibitor (IC50= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in researching liver cancer. | |||||||||||||||||||||
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