2770832-90-9
Chemical Structure
AChE-IN-10
- CAS No.: 2770832-90-9
- Formula:C23H27F2NO4S
- Molecular Weight:451.53
IUPAC Name: 2-fluoro-2-((1-(3-fluorobenzyl)piperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydrobenzo[b]thiophene 1,1-dioxide
InChIKey: IVJYMZOWJKEUNR-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(CC(CC3CCN(CC3)CC4=CC=CC(F)=C4)(S2(=O)=O)F)=C1)OC
Biological Activity: AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE[1].
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AChE-IN-10 | AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE. | |||||||||||||||||||||
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Keywords
