2784631-30-5
2784631-30-5
Chemical Structure
Purine phosphoribosyltransferase-IN-2
- CAS No.: 2784631-30-5
- Formula:C11H15N5Na4O10P2
- Molecular Weight:531.17
IUPAC Name: sodium (((S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((S)-2-hydroxy-2-phosphonatoethoxy)propoxy)methyl)phosphonate
InChIKey: CVTIKPWJHQIBIG-PDFZZBEWSA-J
SMILES: O=P(O[Na])(O[Na])COC[C@@H](OC[C@H](P(O[Na])(O[Na])=O)O)CN1C=NC2=C1N=C(N)NC2=O
Biological Activity: Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively[1].
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Purine phosphoribosyltransferase-IN-2 | Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively. | |||||||||||||||||||||
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References
