2789716-24-9
Chemical Structure
GLyT2-IN-3
- CAS No.: 2789716-24-9
- Formula:C23H31N3O4
- Molecular Weight:413.51
InChIKey: UUFPLFUVPFWWTQ-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(C2=CC=NC=C2)CC1)C3=CC(OC)=C(OCCCC)C(OC)=C3
Biological Activity: GLyT2-IN-3 is a potent GlyT2 inhibitor with a KD of 23.7 nM. GLyT2-IN-3 inhibits GlyT2-mediated glycine uptake with an IC50 of 19.4 nM. GLyT2-IN-3 shows broad-spectrum antinociceptive effects in three pain models, does not induce sedative effects or motor coordination impairment in mice, and exhibits favorable pharmacokinetic properties in rats with an oral bioavailability of 88.57%, GLyT2-IN-3 can be used for the study of neuropathic pain[1].
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GLyT2-IN-3 | GLyT2-IN-3 is a potent GlyT2 inhibitor with a KD of 23.7 nM. GLyT2-IN-3 inhibits GlyT2-mediated glycine uptake with an IC50 of 19.4 nM. GLyT2-IN-3 shows broad-spectrum antinociceptive effects in three pain models, does not induce sedative effects or motor coordination impairment in mice, and exhibits favorable pharmacokinetic properties in rats with an oral bioavailability of 88.57%, GLyT2-IN-3 can be used for the study of neuropathic pain. | |||||||||||||||||||||
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Keywords
