282536-25-8
Chemical Structure
PNU-183792
- CAS No.: 282536-25-8
- Formula:C23H24ClN3O3
- Molecular Weight:425.91
IUPAC Name: N-(4-chlorobenzyl)-1-methyl-6-(morpholinomethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
InChIKey: SXLQSQMKOYVAAW-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C)C2=CC=C(CN3CCOCC3)C=C2C1=O)NCC4=CC=C(C=C4)Cl
Biological Activity: PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PNU-183792 | 98.88% | PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV). | ||||||||||||||||||||
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Keywords
