PNU-183792

Cat. No.: HY-148852 Purity: 98.88%: Data Sheet
COA

SDS
Handling Instructions
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PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC₅₀ values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV).

For research use only. We do not sell to patients.

PNU-183792 Chemical Structure

CAS No. : 282536-25-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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HSV-1 HSV-2 HSV

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	> 100 μM Compound: PNU-183792	Toxicity on uninfected human foreskin fibroblast cells determined in microscopic evaluation and quantitative neutral red dye uptake assay Toxicity on uninfected human foreskin fibroblast cells determined in microscopic evaluation and quantitative neutral red dye uptake assay	[PMID: 16134946]
HFF	IC₅₀	0.34 μM Compound: PNU-183792	Antiviral activity against Varicella-Zoster virus (Webster strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed Antiviral activity against Varicella-Zoster virus (Webster strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed	[PMID: 16134946]
HFF	IC₅₀	0.9 μM Compound: PNU-183792	Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO	[PMID: 16134946]
HFF	IC₅₀	300 nM Compound: 1	Antiviral activity against Human cytomegalovirus infected in HFF cells by plaque reduction assay Antiviral activity against Human cytomegalovirus infected in HFF cells by plaque reduction assay	[PMID: 20167488]
Sf9	IC₅₀	690 nM Compound: 1	Inhibition of HCMV recombinant DNA polymerase expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assay Inhibition of HCMV recombinant DNA polymerase expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assay	[PMID: 20167488]
Vero	CC₅₀	> 100 μM Compound: PNU-183792	Toxicity on uninfected African green monkey kidney cells determined in microscopic evaluation and quantitative neutral red dye uptake assay Toxicity on uninfected African green monkey kidney cells determined in microscopic evaluation and quantitative neutral red dye uptake assay	[PMID: 16134946]
Vero	IC₅₀	3.5 μM Compound: PNU-183792	Antiviral activity against herpes simplex virus type 1 (KOS strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed Antiviral activity against herpes simplex virus type 1 (KOS strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed	[PMID: 16134946]

Molecular Weight

425.91

Formula

C₂₃H₂₄ClN₃O₃

CAS No.

282536-25-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C)C2=CC=C(CN3CCOCC3)C=C2C1=O)NCC4=CC=C(C=C4)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (29.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3479 mL	11.7396 mL	23.4791 mL
5 mM	0.4696 mL	2.3479 mL	4.6958 mL
10 mM	0.2348 mL	1.1740 mL	2.3479 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.88%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (278 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Brideau RJ, et al. Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses. Antiviral Res. 2002 Apr;54(1):19-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3479 mL	11.7396 mL	23.4791 mL	58.6978 mL
	5 mM	0.4696 mL	2.3479 mL	4.6958 mL	11.7396 mL
	10 mM	0.2348 mL	1.1740 mL	2.3479 mL	5.8698 mL
	15 mM	0.1565 mL	0.7826 mL	1.5653 mL	3.9132 mL
	20 mM	0.1174 mL	0.5870 mL	1.1740 mL	2.9349 mL
	25 mM	0.0939 mL	0.4696 mL	0.9392 mL	2.3479 mL

PNU-183792 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU-183792282536-25-8PNU183792PNU 183792HSVHerpes simplex virusHSV polymerases inhibitororally activeantiviral activitysimian varicella virus (SVV)murine cytomegalovirus (MCMV)rat cytomegalovirus (RCMV)Inhibitorinhibitorinhibit

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PNU-183792

PNU-183792 Related Antibodies

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Biological Activity

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References

Customer Review

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