2826215-20-5
Chemical Structure
PROTAC IKKβ/NR4A1 degrader-1
- CAS No.: 2826215-20-5
- Formula:C48H60N4O7
- Molecular Weight:805.01
InChIKey: GHKWHOZOJQTHNK-FRMFTZQOSA-N
SMILES: [H][C@@]12C[C@](C(NCCCCCCNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)(CC[C@@]1(CC[C@@]6(C7=CC=C8C([C@@]7(CC[C@]62C)C)=CC(C(O)=C8C)=O)C)C)C
Biological Activity: PROTAC IKKβ/NR4A1 degrader-1 is a highly efficient and effective dual-PROTAC degrader targeting IKKβ and NR4A1. PROTAC IKKβ/NR4A1 degrader-1 can increase the levels of caspase 3 and cleaved caspase 3 proteins, while the necroptosis marker RIP kinase remained unchanged, indicating that it can induce apoptosis. PROTAC IKKβ/NR4A1 degrader-1 can be used for the study of Acute myeloid leukemia (AML). Red: IKKβ/NR4A1 ligand (HY-13067); Blue: E3 ligase CRBN ligand (HY-14658); Black: Linker (HY-79577)[1].
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PROTAC IKKβ/NR4A1 degrader-1 | PROTAC IKKβ/NR4A1 degrader-1 is a highly efficient and effective dual-PROTAC degrader targeting IKKβ and NR4A1. PROTAC IKKβ/NR4A1 degrader-1 can increase the levels of caspase 3 and cleaved caspase 3 proteins, while the necroptosis marker RIP kinase remained unchanged, indicating that it can induce apoptosis. PROTAC IKKβ/NR4A1 degrader-1 can be used for the study of Acute myeloid leukemia (AML). Red: IKKβ/NR4A1 ligand (HY-13067); Blue: E3 ligase CRBN ligand (HY-14658); Black: Linker (HY-79577). | |||||||||||||||||||||
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Keywords
