2831492-41-0
Chemical Structure
Apoptosis inducer 36
- CAS No.: 2831492-41-0
- Formula:C23H40O3Si
- Molecular Weight:392.65
InChIKey: PTZCUVWARXPJPZ-ANZUNKEZSA-N
SMILES: [H][C@@]12CC(C(O[C@@H]1CC[C@@]3([C@H](CC[C@]32[H])O[Si](C(C)C)(C(C)C)C(C)C)C)=O)=C
Biological Activity: Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model[1].
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Apoptosis inducer 36 | Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model. | |||||||||||||||||||||
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Keywords
