284019-34-7
Chemical Structure
Denibulin
Synonym(s): MN-029 free base
- CAS No.: 284019-34-7
- Formula:C18H19N5O3S
- Molecular Weight:385.44
IUPAC Name: (S)-methyl (5-((4-(2-aminopropanamido)phenyl)thio)-1H-benzo[d]imidazol-2-yl)carbamate
InChIKey: GAOHLWCIAJNSEE-JTQLQIEISA-N
SMILES: O=C(OC)NC1=NC2=CC(SC3=CC=C(NC([C@@H](N)C)=O)C=C3)=CC=C2N1
Biological Activity: Denibulin, a novel vascular-disrupting agent, inhibits microtubule assembly reversibly, disrupting tumor vascular endothelial cell cytoskeletons. Denibulin demonstrated tolerability and potential anti-vascular effects, warranting further investigation in cancer therapy[1].
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Denibulin | Denibulin, a novel vascular-disrupting agent, inhibits microtubule assembly reversibly, disrupting tumor vascular endothelial cell cytoskeletons. Denibulin demonstrated tolerability and potential anti-vascular effects, warranting further investigation in cancer therapy. | |||||||||||||||||||||
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Keywords
