2848720-31-8
Chemical Structure
microRNA-21-IN-1
- CAS No.: 2848720-31-8
- Formula:C30H37FN6O3
- Molecular Weight:548.65
IUPAC Name: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-N-(4-((2-(piperidin-1-yl)ethyl)carbamoyl)phenyl)-1,4-dihydroquinoline-3-carboxamide
InChIKey: QZVASKUJNDLONM-UHFFFAOYSA-N
SMILES: CCN1C=C(C(C2=CC(F)=C(C=C21)N3CCNCC3)=O)C(NC4=CC=C(C=C4)C(NCCN5CCCCC5)=O)=O
Biological Activity: microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer[1].
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microRNA-21-IN-1 | 98.03% | microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer. | ||||||||||||||||||||
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Keywords
