2850362-12-6
2850362-12-6
Chemical Structure
HLB-0532247
- CAS No.: 2850362-12-6
- Formula:C21H27N4O8P
- Molecular Weight:494.43
InChIKey: LWNCAGWHAKUXIC-GTKRBQPSSA-N
SMILES: NC(C=CN1[C@H]2[C@H](O)C=C(CO[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)O2)=NC1=O
Biological Activity: HLB-0532247 is a cell-permeable phosphoramidate prodrug of 3'-deoxy-3',4'-didehydrocytidine (ddhC). HLB-0532247 increases the intracellular level of the endogenous antiviral nucleotide ddhCTP (HY-128788). HLB-0532247 reduces the titers of Zika virus and West Nile virus in cell cultures. HLB-0532247 can be used in studies related to Zika virus infection, West Nile virus infection, and coronavirus infection[1][2].
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HLB-0532247 | HLB-0532247 is a cell-permeable phosphoramidate prodrug of 3'-deoxy-3',4'-didehydrocytidine (ddhC). HLB-0532247 increases the intracellular level of the endogenous antiviral nucleotide ddhCTP (HY-128788). HLB-0532247 reduces the titers of Zika virus and West Nile virus in cell cultures. HLB-0532247 can be used in studies related to Zika virus infection, West Nile virus infection, and coronavirus infection. | |||||||||||||||||||||
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References
- [1]. Passow KT, et al. A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide. J Med Chem. 2021;64(20):15429-15439. [Content Brief]
- [2]. Zhu M, et al. CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner. PLoS Biol. 2023;21(3):e3002039. Published 2023 Mar 17. [Content Brief]
