2854-32-2
2854-32-2
Chemical Structure
BML-190
Synonym(s): Indomethacin morpholinylamide; IMMA
- CAS No.: 2854-32-2
- Formula:C23H23ClN2O4
- Molecular Weight:426.89
IUPAC Name: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethan-1-one
InChIKey: BJSDNVVWJYDOLK-UHFFFAOYSA-N
SMILES: CC(N1C(C2=CC=C(Cl)C=C2)=O)=C(CC(N3CCOCC3)=O)C4=C1C=CC(OC)=C4
Biological Activity:
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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BML-190 | 99.53% | BML-190(IMMA) is a potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 μM for CB2 and CB1 respectively). | ||||||||||||||||||||
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References
- Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences (
- Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786. [Content Brief]
- New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60. [Content Brief]
