2866211-93-8
Chemical Structure
GEM–IB
- CAS No.: 2866211-93-8
- Formula:C18H33F2N4O13P3
- Molecular Weight:644.39
IUPAC Name: (2R,3R)-8-(1-ethyl-5-oxopyrrolidin-2-yl)-5,7-dihydroxy-2-(3,4,6-trihydroxy-5-oxo-8-((2R)-3,5,7-trihydroxychroman-2-yl)-5H-benzo[7]annulen-1-yl)chroman-3-yl 3,4,5-trihydroxybenzoate
InChIKey: DBLRORCIGRERLK-UBEPTHPKSA-N
SMILES: CCCCCN(CCC(P(O)(O)=O)(P(O)(OP(O)(OC[C@H]1O[C@H](C(F)([C@@H]1O)F)N2C=CC(N)=NC2=O)=O)=O)O)C
Biological Activity: GEM–IB is the conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB). GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS)[1].
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GEM–IB | GEM–IB is the conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB). GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS). | |||||||||||||||||||||
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