288-14-2
288-14-2
Chemical Structure
Isoxazole
- CAS. Nr.: 288-14-2
- Formula:C3H3NO
- Molecular Weight:69.06
IUPAC Name: isoxazole
InChIKey: CTAPFRYPJLPFDF-UHFFFAOYSA-N
SMILES: C1=CON=C1
Biological Activity: Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor[1][2][3][4][5].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Isoxazole | 99.98% | Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor. | ||||||||||||||||||||
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Isoxazole (Standard) | ≥98% | Isoxazole (Standard) is the analytical standard of Isoxazole (HY-W010649). This product is intended for research and analytical applications. Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor?. | ||||||||||||||||||||
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Oxazole | 99.98% | 1,3-Oxazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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1H-pyrazole (Standard) | ≥98% | 1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally active antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis. | ||||||||||||||||||||
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Imidazole (Standard) | ≥98% | Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease. | ||||||||||||||||||||
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1H-Imidazole hydrochloride | 99.96% | 1H-Imidazole hydrochloride can be used as ligand, buffer and catalyst, etc., and also plays an important role in the process of drug synthesis and extraction of natural products. In addition, the compound is widely used in certain industrial fields, such as in the manufacturing process of plastics, coatings, textiles and electronic materials. Although the compound has no direct medical applications, it plays an important role in chemical research and laboratory studies. | ||||||||||||||||||||
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Isoxazol-3-amine | 98.86% | Isoxazol-3-amine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Pyridazine | 99.78% | Pyridazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Imidazole-15N2 | 98.56% | Imidazole-15N2 (Glyoxaline-15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease. | ||||||||||||||||||||
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Pyrimidine | 99.99% | Pyrimidine is a nitrogen-containing heterocyclic compound that serves as a scaffold for numerous natural and synthetic derivatives. As a pharmacophore, pyrimidine interacts with the synthesis and function of nucleic acids. Pyrimidine derivatives are used in research related to pancreatic cancer, triple-negative breast cancer, colon cancer, and leukemia. | ||||||||||||||||||||
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References
- [1]. Zhu J, et al. The recent progress of isoxazole in medicinal chemistry. Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075. [Content Brief]
- [2]. Sysak A, et al. Isoxazole ring as a useful scaffold in a search for new therapeutic agents. Eur J Med Chem. 2017 Sep 8;137:292-309. [Content Brief]
- [3]. Norman BH, et al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)[J]. Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. [Content Brief]
- [4]. Agrawal N, Mishra P. The synthetic and therapeutic expedition of isoxazole and its analogs[J]. Med Chem Res. 2018;27(5):1309-1344. [Content Brief]
- [5]. Kalwat MA, et al. Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells. ACS Chem Biol. 2016 Apr 15;11(4):1128-36. [Content Brief]
