288247-87-0
288247-87-0
Chemical Structure
T-2513
- CAS 番号: 288247-87-0
- Formula:C25H27N3O5
- Molecular Weight:449.50
IUPAC Name: (S)-9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
InChIKey: XZLHHOGJQUVONU-VWLOTQADSA-N
SMILES: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(OCCCN)=CC=C5N=C4C3=C2)=O
Biological Activity: T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].
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T-2513 | T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death. | |||||||||||||||||||||
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