2883232-46-8
2883232-46-8
Chemical Structure
MurB-IN-1
- CAS No.: 2883232-46-8
- Formula:C12H7Cl2F3N2O2
- Molecular Weight:339.10
IUPAC Name: (2S,3aS,7aS)-1-(((S)-1-ethoxy-1-oxopentan-2-yl)-L-alanyl-2,3,3,3-d4)octahydro-1H-indole-2-carboxylic acid
InChIKey: WTBZVBPKXQSZFK-UHFFFAOYSA-N
SMILES: CC1=CC(Cl)=C(C=C1N2N=CC(C(O)=O)=C2C(F)(F)F)Cl
Biological Activity: MurB-IN-1 is an inhibitor of Pseudomonas aeruginosa UDP-N-acetylmuramic acid enolpyruvyl reductase (MurB) with a Kd value of 3.57 μM. MurB-IN-1 is applicable to the research of Pseudomonas aeruginosa infections (cystic fibrosis-associated)[1].
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MurB-IN-1 | MurB-IN-1 is an inhibitor of Pseudomonas aeruginosa UDP-N-acetylmuramic acid enolpyruvyl reductase (MurB) with a Kd value of 3.57 μM. MurB-IN-1 is applicable to the research of Pseudomonas aeruginosa infections (cystic fibrosis-associated). | |||||||||||||||||||||
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References
- [1]. Acebrón-García-de-Eulate M, et, al. Discovery of Novel Inhibitors of Uridine Diphosphate- N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. J Med Chem. 2022 Feb 10;65(3):2149-2173. [Content Brief]
