2891451-33-3
Chemical Structure
RNA polymerase II-IN-2
- CAS No.: 2891451-33-3
- Formula:C41H58N10O12S
- Molecular Weight:915.02
IUPAC Name: ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
InChIKey: MKNZJEOQVOIWCY-STUWASOWSA-N
SMILES: O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
Biological Activity: RNA polymerase II-IN-2 is a RNA polymerase II inhibitor with a Ki value of 74.1 nM. RNA polymerase II-IN-2 inhibits Pol II-mediated transcription and induces cytotoxicity in mammalian cells. RNA polymerase II-IN-2 serves as a payload for antibody-drug conjugates (ADC) and is applicable for cancer research[1].
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RNA polymerase II-IN-2 | RNA polymerase II-IN-2 is a RNA polymerase II inhibitor with a Ki value of 74.1 nM. RNA polymerase II-IN-2 inhibits Pol II-mediated transcription and induces cytotoxicity in mammalian cells. RNA polymerase II-IN-2 serves as a payload for antibody-drug conjugates (ADC) and is applicable for cancer research. | |||||||||||||||||||||
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