1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. RNA polymerase II-IN-2

RNA polymerase II-IN-2 

Cat. No.: HY-147917
Handling Instructions

RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293.

For research use only. We do not sell to patients.

RNA polymerase II-IN-2 Chemical Structure

RNA polymerase II-IN-2 Chemical Structure

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Description

RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293[1].

IC50 & Target

Ki: 74.1 nM (Pol II)[1]

Molecular Weight

915.02

Formula

C41H58N10O12S

SMILES

O=C([[email protected]](C(CC)CC)NC(CNC1=O)=O)NCC(N[[email protected]@H]2C(N[[email protected]](C(N3C[[email protected]@H](C[[email protected]]3C(N[[email protected]](C(N[[email protected]]1CC4=C(S[[email protected]]2C)NC5=C4C=CC=C5)=O)[[email protected]]([[email protected]](CO)O)C)=O)O)=O)CC(N)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
RNA polymerase II-IN-2
Cat. No.:
HY-147917
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