RNA polymerase II-IN-2
RNA polymerase II-IN-2 is a RNA polymerase II inhibitor with a Ki value of 74.1 nM. RNA polymerase II-IN-2 inhibits Pol II-mediated transcription and induces cytotoxicity in mammalian cells. RNA polymerase II-IN-2 serves as a payload for antibody-drug conjugates (ADC) and is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2891451-33-3
- Formula: C41H58N10O12S
- Molecular Weight:915.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.61 μM
Compound: 20iii
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Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 35696491] |
| HEK293 | IC50 |
0.2 μM
Compound: 20iii
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 35696491] |
| HeLa | IC50 |
0.6 μM
Compound: 20iii
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 35696491] |
| HepG2 | IC50 |
0.11 μM
Compound: 20iii
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 35696491] |
RNA polymerase II-IN-2 (20iii) is nearly twice as cytotoxic to CHO cells as α-amanitin, with a normalized IC50 value of 0.61[1].
RNA polymerase II-IN-2 is 5-fold more cytotoxic to HEK293 cells than α-amanitin, with a normalized IC50 value of 0.20[1].
RNA polymerase II-IN-2 is more cytotoxic to HeLa cells than α-amanitin, with a normalized IC50 value of 0.60[1].
RNA polymerase II-IN-2 is significantly less cytotoxic to HepG2 liver-derived cells than α-amanitin, with a normalized IC50 value of 2.7[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2891451-33-3
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Molecular Weight 915.02
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Formula C41H58N10O12S
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SMILES
O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RNA polymerase II-IN-2 Related Classifications
HY-147917 Related Classifications
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