2891466-35-4
2891466-35-4
Chemical Structure
AQP4 (205-215)
- CAS No.: 2891466-35-4
- Formula:C48H75N13O17S
- Molecular Weight:1138.25
InChIKey: MBLWMNPXZGONOT-CEPVBHPHSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(N)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO)[1][2].
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AQP4 (205-215) | AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO). | |||||||||||||||||||||
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References
- [1]. Ali Maisam Afzali, et al. B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. 2024 Mar;627(8003):407-415. [Content Brief]
- [2]. Anna-Lena Vogel, et al. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol. 2017 Mar;47(3):458-469. [Content Brief]
