2892822-24-9
2892822-24-9
Chemical Structure
WZ-1831
- CAS No.: 2892822-24-9
- Formula:C25H29BN4O6
- Molecular Weight:492.33
IUPAC Name: (2S,3R,4S)-2-((2-chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)methyl)tetrahydroselenophene-3,4-diol
InChIKey: ATSWPXLAIPHFLB-FQEVSTJZSA-N
SMILES: OB(O)C1=CC=CC(CNC([C@H](CC(NC(C)(C)C)=O)NC(C(C2=CNC3=CC=CC=C23)=O)=O)=O)=C1
Biological Activity: WZ-1831 is a selective inhibitor of the constitutive proteasome β5c subunit (IC50 0.01 μM). WZ-1831 exhibits anticancer activity against multiple myeloma. WZ-1831 synergizes with the β5i-selective inhibitor PKS21265 to induce cytotoxicity. WZ-1831 can be used for research on multiple myeloma[1][2].
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WZ-1831 | WZ-1831 is a selective inhibitor of the constitutive proteasome β5c subunit (IC50 0.01 μM). WZ-1831 exhibits anticancer activity against multiple myeloma. WZ-1831 synergizes with the β5i-selective inhibitor PKS21265 to induce cytotoxicity. WZ-1831 can be used for research on multiple myeloma. | |||||||||||||||||||||
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References
- [1]. Zhan W, et al. Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit. Journal of medicinal chemistry. 2023 Jan 26;66(2):1172-1185. [Content Brief]
- [2]. Laurent P, et al. The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity. Proceedings of the National Academy of Sciences of the United States of America. 2025 Nov 25;122(47):e2518190122. [Content Brief]
