2894121-83-4
2894121-83-4
Chemical Structure
Eleven-Nineteen-Leukemia Protein IN-3
- CAS No.: 2894121-83-4
- Formula:C28H27N5O2
- Molecular Weight:465.55
IUPAC Name: (S)-5-methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-6-oxo-5,6-dihydrophenanthridine-2-carboxamide
InChIKey: CCTWWXZPDOYAIL-KRWDZBQOSA-N
SMILES: C[C@H]1CCCN1CC2=NC3=CC(NC(C4=CC=C5C(C6=CC=CC=C6C(N5C)=O)=C4)=O)=CC=C3N2
Biological Activity: Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC50 value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro[1].
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Eleven-Nineteen-Leukemia Protein IN-3 | Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC50 value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro. | |||||||||||||||||||||
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