2904690-41-9
Chemical Structure
TRK II-IN-1
- CAS No.: 2904690-41-9
- Formula:C29H31F3N8O
- Molecular Weight:564.60
IUPAC Name: (R)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-1-(3-(pyridin-2-yl)imidazo[1,2-b]pyridazin-6-yl)pyrrolidine-3-carboxamide
InChIKey: WYCSRUVPJUYDGP-OAQYLSRUSA-N
SMILES: CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC([C@@H]3CCN(C3)C4=NN5C(C6=NC=CC=C6)=CN=C5C=C4)=O
Biological Activity: TRK II-IN-1 is a potent type II TRK inhibitor, with IC50s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKAG667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC50s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers[1].
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TRK II-IN-1 | TRK II-IN-1 is a potent type II TRK inhibitor, with IC50s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKAG667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC50s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers. | |||||||||||||||||||||
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