2913177-53-2
Chemical Structure
YF135
- CAS 番号: 2913177-53-2
- Formula:C63H75ClN12O7S
- Molecular Weight:1179.86
IUPAC Name: 4,4,5,5-tetramethyl-2-(3-(2,2,2-trifluoroethyl)phenyl)-1,3,2-dioxaborolane
InChIKey: VJEBOMJUVXOGQI-ZAONMBGGSA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCOCCCN4CCC[C@H]4COC5=NC6=C(C(N7CCN([C@H](C7)CC#N)C(/C(C#N)=C/C8CC8)=O)=N5)CCN(C6)C9=CC=CC%10=C9C(Cl)=CC=C%10)=O)=O)O)=O
Biological Activity: YF135 is a KRASG12C PROTAC degrader that mediates proteasomal degradation of KRASG12C in a reversible manner. In KRASG12C-mutant H358 and H23 lung cancer cells, the DC50 values of YF135 for KRAS degradation are 3.61 μM and 4.53 μM, respectively. YF135 attenuates the pERK signaling pathway in cancer cells. YF135 is applicable for lung cancer-related research[1].
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YF135 | YF135 is a KRASG12C PROTAC degrader that mediates proteasomal degradation of KRASG12C in a reversible manner. In KRASG12C-mutant H358 and H23 lung cancer cells, the DC50 values of YF135 for KRAS degradation are 3.61 μM and 4.53 μM, respectively. YF135 attenuates the pERK signaling pathway in cancer cells. YF135 is applicable for lung cancer-related research. | |||||||||||||||||||||
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Keywords
