2920000-86-6
2920000-86-6
Chemical Structure
HPK1-IN-33
- CAS No.: 2920000-86-6
- Formula:C18H16ClFN6
- Molecular Weight:370.81
IUPAC Name: 3-(4-((3S,4R)-3-amino-4-fluoropiperidin-1-yl)-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
InChIKey: PPGUULSJUXLSJS-OLZOCXBDSA-N
SMILES: N#CC1=CC(C2=C(NC3=NC=NC(N4CC[C@H]([C@H](C4)N)F)=C32)Cl)=CC=C1
Biological Activity: HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC50s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively[1].
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HPK1-IN-33 | HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC50s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively. | |||||||||||||||||||||
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