HPK1-IN-33
HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC50s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2920000-86-6
- Formula: C18H16ClFN6
- Molecular Weight:370.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All MAP4K Isoforms
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Biological Activity
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HPK1 1.7 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
286 nM
Compound: 21
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Inhibition of IL-2 production in wild type human T-activator CD3/CD28-stimulated human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis
Inhibition of IL-2 production in wild type human T-activator CD3/CD28-stimulated human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis
|
[PMID: 36940470] |
| Jurkat | EC50 |
>10000 nM
Compound: 21
|
Inhibition of IL-2 production in human T-activator CD3/CD28-stimulated HPK1 knockout human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis
Inhibition of IL-2 production in human T-activator CD3/CD28-stimulated HPK1 knockout human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis
|
[PMID: 36940470] |
Chemical Information
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CAS No. 2920000-86-6
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Molecular Weight 370.81
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Formula C18H16ClFN6
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SMILES
N#CC1=CC(C2=C(NC3=NC=NC(N4CC[C@H]([C@H](C4)N)F)=C32)Cl)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)