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Referencia número: HY-149206

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HPK1-IN-33

HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a K_i value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC₅₀s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively.

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No. CAS: 2920000-86-6
Fòrmula: C₁₈H₁₆ClFN₆
Peso molecular:370.81

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

HPK1-IN-33 Chemical Structure

No. CAS: 2920000-86-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

HPK1

1.7 nM (Ki)

Ver todos los productos específicos de isoformas MAP4K :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	EC₅₀	286 nM Compound: 21	Inhibition of IL-2 production in wild type human T-activator CD3/CD28-stimulated human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis Inhibition of IL-2 production in wild type human T-activator CD3/CD28-stimulated human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis	[PMID: 36940470]
Jurkat	EC₅₀	>10000 nM Compound: 21	Inhibition of IL-2 production in human T-activator CD3/CD28-stimulated HPK1 knockout human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis Inhibition of IL-2 production in human T-activator CD3/CD28-stimulated HPK1 knockout human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis	[PMID: 36940470]

Chemical Information

No. CAS 2920000-86-6
Peso molecular 370.81
Fòrmula C₁₈H₁₆ClFN₆
SMILES

N#CC1=CC(C2=C(NC3=NC=NC(N4CC[C@H]([C@H](C4)N)F)=C32)Cl)=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gallego RA, et al. Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J Med Chem. 2023 Mar 20. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
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HPK1-IN-33

Ver todos los productos específicos de isoformas MAP4K

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

HPK1-IN-33 Related Classifications

HY-149206 Related Classifications