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Art. -Nr.: HY-149206

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HPK1-IN-33

HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a K_i value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC₅₀s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively.

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CAS. Nr.: 2920000-86-6
Formel: C₁₈H₁₆ClFN₆
Molecular Weight:370.81

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

HPK1-IN-33 Chemical Structure

CAS. Nr.: 2920000-86-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

HPK1

1.7 nM (Ki)

Alle MAP4K Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	EC₅₀	286 nM Compound: 21	Inhibition of IL-2 production in wild type human T-activator CD3/CD28-stimulated human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis Inhibition of IL-2 production in wild type human T-activator CD3/CD28-stimulated human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis	[PMID: 36940470]
Jurkat	EC₅₀	>10000 nM Compound: 21	Inhibition of IL-2 production in human T-activator CD3/CD28-stimulated HPK1 knockout human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis Inhibition of IL-2 production in human T-activator CD3/CD28-stimulated HPK1 knockout human Jurkat cells preincubated for 30 mins followed by CD3/CD28 addition and measured after 24 hrs by ELISA analysis	[PMID: 36940470]

Chemical Information

CAS. Nr. 2920000-86-6
Molecular Weight 370.81
Formel C₁₈H₁₆ClFN₆
SMILES

N#CC1=CC(C2=C(NC3=NC=NC(N4CC[C@H]([C@H](C4)N)F)=C32)Cl)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gallego RA, et al. Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J Med Chem. 2023 Mar 20. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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HPK1-IN-33

Alle MAP4K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HPK1-IN-33 Related Classifications

HY-149206 Related Classifications

Bioz

Keywords

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