2922929-63-1
Chemical Structure
ER degrader 7
- CAS No.: 2922929-63-1
- Formula:C33H31F4N3O5SSe
- Molecular Weight:736.63
InChIKey: UBCZFNCFEZWGPP-IKLPKNCVSA-N
SMILES: O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC(F)(F)F)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1
Biological Activity: ER degrader 7 is an estrogen receptor α (ERα) degrader and a tubulin (tubulin) inhibitor. ER degrader 7 inhibits the cell viability of various cancer cell lines. ER degrader 7 disrupts the microtubule network in breast cancer cells, induces G2/M phase cell cycle arrest, and exhibits concentration-dependent accumulation in Tamoxifen-resistant LCC2 cells. ER degrader 7 suppresses tumor growth in vivo without causing body weight loss. ER degrader 7 can be applied in studies related to breast cancer[1].
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ER degrader 7 | ER degrader 7 is an estrogen receptor α (ERα) degrader and a tubulin (tubulin) inhibitor. ER degrader 7 inhibits the cell viability of various cancer cell lines. ER degrader 7 disrupts the microtubule network in breast cancer cells, induces G2/M phase cell cycle arrest, and exhibits concentration-dependent accumulation in Tamoxifen-resistant LCC2 cells. ER degrader 7 suppresses tumor growth in vivo without causing body weight loss. ER degrader 7 can be applied in studies related to breast cancer. | |||||||||||||||||||||
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