2924156-46-5
2924156-46-5
Chemical Structure
Anti-inflammatory agent 54
- CAS No.: 2924156-46-5
- Formula:C17H16N2O5
- Molecular Weight:328.32
InChIKey: RUTHXBPCZRIDSB-FNORWQNLSA-N
SMILES: O=C(/C=C/C1=CC=CO1)NCCN2C3=CC=C(OC)C=C3OC2=O
Biological Activity: Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].
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Anti-inflammatory agent 54 | Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model. | |||||||||||||||||||||
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