2924858-30-8
2924858-30-8
Chemical Structure
Thalidomide-N-methylpiperazine
- CAS No.: 2924858-30-8
- Formula:C18H20N4O4
- Molecular Weight:356.38
InChIKey: QCWYNTQEGFDVSU-UHFFFAOYSA-N
SMILES: CN1CCN(C2=CC3=C(C=C2)C(N(C3=O)C4CCC(NC4=O)=O)=O)CC1
Biological Activity: Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) [1] to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model[1].
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Thalidomide-N-methylpiperazine | Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model. | |||||||||||||||||||||
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References
Keywords
