2929236-94-0
Chemical Structure
Ratutrelvir
Synonym(s): TRX01
- CAS No.: 2929236-94-0
- Formula:C27H32F3N5O4
- Molecular Weight:547.57
InChIKey: VVIHXCHAXVESGZ-MXEWLHNESA-N
SMILES: CC1(C)[C@](CN2C([C@H](C(C)(C)C)NC(C(F)(F)F)=O)=O)([H])[C@@]1([H])[C@H]2C(N[C@@H](CC3C(NC4=CC=CC=C43)=O)C#N)=O
Biological Activity: Ratutrelvir is a NF-κB p65 inhibitor. Ratutrelvir blocks the translocation of NF-κB p65 from the cytoplasm to the nucleus, reduces the phosphorylation levels of NF-κB p65 and IκBα, and inhibits the DNA-binding activity of NF-κB p65. Ratutrelvir inhibits the migration and invasion abilities of breast cancer cells, and reduces their viability and colony-forming capacity. Ratutrelvir can be used for the research of luminal A breast cancer[1].
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Ratutrelvir | Ratutrelvir is a NF-κB p65 inhibitor. Ratutrelvir blocks the translocation of NF-κB p65 from the cytoplasm to the nucleus, reduces the phosphorylation levels of NF-κB p65 and IκBα, and inhibits the DNA-binding activity of NF-κB p65. Ratutrelvir inhibits the migration and invasion abilities of breast cancer cells, and reduces their viability and colony-forming capacity. Ratutrelvir can be used for the research of luminal A breast cancer. | |||||||||||||||||||||
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