2931499-82-8
2931499-82-8
Chemical Structure
EGFR/HER2-IN-10
- CAS No.: 2931499-82-8
- Formula:C29H24ClF3N6O5
- Molecular Weight:628.99
InChIKey: OWTCMGIQRBBCSW-UHFFFAOYSA-N
SMILES: O=[N+](C1=NC=CN1CCCCOC2=CC3=C(NC4=CC=C(OC5=CC=CC(C(F)(F)F)=C5)C(Cl)=C4)N=CN=C3C=C2OC)[O-]
Biological Activity: EGFR/HER2-IN-10 (compound 9F) is a potent and selective dual EGFR/HER2 inhibitor with IC50s of 2.3 nM and 234 nM for EGFR and HER2, respectively. EGFR/HER2-IN-10 shows an effective antiproliferative action against prostate carcinoma[1].
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EGFR/HER2-IN-10 | EGFR/HER2-IN-10 (compound 9F) is a potent and selective dual EGFR/HER2 inhibitor with IC50s of 2.3 nM and 234 nM for EGFR and HER2, respectively. EGFR/HER2-IN-10 shows an effective antiproliferative action against prostate carcinoma. | |||||||||||||||||||||
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