2935587-89-4
Chemical Structure
PROTAC CDK9 degrader-5
- CAS No.: 2935587-89-4
- Formula:C42H48Cl2N8O9
- Molecular Weight:879.78
IUPAC Name: 4-(2,6-dichlorobenzamido)-N-(1-(11-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)undecanoyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide
InChIKey: DZJCTNGKFRUZQI-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCCCCCC(N1CCC(CC1)NC(C2=NNC=C2NC(C3=C(C=CC=C3Cl)Cl)=O)=O)=O)COC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O
Biological Activity: PROTAC CDK9 degrader-5 is a PROTAC degrader that specifically targets CDK9. PROTAC CDK9 degrader-5 degrades CDK9, with DC50 values of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively. PROTAC CDK9 degrader-5 induces ubiquitination of CDK9 followed by proteasomal degradation. PROTAC CDK9 degrader-5 reduces the expression levels of the short-lived pro-survival proteins MCL-1 and c-Myc. PROTAC CDK9 degrader-5 can be used for research related to acute myeloid leukemia[1].
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PROTAC CDK9 degrader-5 | PROTAC CDK9 degrader-5 is a PROTAC degrader that specifically targets CDK9. PROTAC CDK9 degrader-5 degrades CDK9, with DC50 values of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively. PROTAC CDK9 degrader-5 induces ubiquitination of CDK9 followed by proteasomal degradation. PROTAC CDK9 degrader-5 reduces the expression levels of the short-lived pro-survival proteins MCL-1 and c-Myc. PROTAC CDK9 degrader-5 can be used for research related to acute myeloid leukemia. | |||||||||||||||||||||
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