2942328-06-3
2942328-06-3
Chemical Structure
LRRK2-IN-14
- CAS No.: 2942328-06-3
- Formula:C17H18F3N5O2
- Molecular Weight:381.35
InChIKey: BAZMNABWFUQBCZ-UHFFFAOYSA-N
SMILES: COC1=C2C=C(C(N(CCCNC3=NC(N2)=NC=C3C(F)(F)F)C)=O)C=C1
Biological Activity: LRRK2-IN-14 (Compound 8) is an orally active LRRK2 inhibitor. LRRK2-IN-14 has an IC50 of 6.3 nM for LRRK2(G2019S) cell activity.LRRK2-IN-14 has an inhibitory effect on hERG (IC50=22 μM). LRRK2-IN-14 has blood-brain barrier permeability[1].
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LRRK2-IN-14 | LRRK2-IN-14 (Compound 8) is an orally active LRRK2 inhibitor. LRRK2-IN-14 has an IC50 of 6.3 nM for LRRK2(G2019S) cell activity.LRRK2-IN-14 has an inhibitory effect on hERG (IC50=22 μM). LRRK2-IN-14 has blood-brain barrier permeability. | |||||||||||||||||||||
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References
Keywords
