2955607-40-4
Chemical Structure
EGFR T790M/L858R-IN-2
- CAS No.: 2955607-40-4
- Formula:C28H28FN7O
- Molecular Weight:497.57
IUPAC Name: N-(3-((6-fluoro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazolin-4-yl)amino)phenyl)acrylamide
InChIKey: KDWNVZXLHSMELQ-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=CC(NC2=C3C=C(F)C=CC3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O
Biological Activity: EGFR T790M/L858R-IN-2 is a potent and selective EGFRT790M/L858R inhibitor with IC50 values of 3.5, 1290 nM for EGFRT790M/L858R, EGFR WT, respectively. EGFR T790M/L858R-IN-2 decreases the expression of p-EGFR, P-AKT, P-ERK1/2. EGFR T790M/L858R-IN-2 induces Apoptosis and cell cycle arrest in the G1 phase. EGFR T790M/L858R-IN-2 shows anti-cancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGFR T790M/L858R-IN-2 | 99.66% | EGFR T790M/L858R-IN-2 is a potent and selective EGFRT790M/L858R inhibitor with IC50 values of 3.5, 1290 nM for EGFRT790M/L858R, EGFR WT, respectively. EGFR T790M/L858R-IN-2 decreases the expression of p-EGFR, P-AKT, P-ERK1/2. EGFR T790M/L858R-IN-2 induces Apoptosis and cell cycle arrest in the G1 phase. EGFR T790M/L858R-IN-2 shows anti-cancer activity. | ||||||||||||||||||||
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Keywords
