2974489-09-1
Chemical Structure
BMS-818251
- CAS No.: 2974489-09-1
- Formula:C29H26N6O5S
- Molecular Weight:570.62
IUPAC Name: 4-(3-(2-(4-(cyano(phenyl)methylene)piperidin-1-yl)-2-oxoacetyl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)-N-(2-hydroxyethyl)thiazole-2-carboxamide
InChIKey: ZVQKONGCGRQCEO-UHFFFAOYSA-N
SMILES: N#C/C(C1=CC=CC=C1)=C2CCN(CC/2)C(C(C3=CNC4=C(C5=CSC(C(NCCO)=O)=N5)N=CC(OC)=C34)=O)=O
Biological Activity: BMS-818251 is a HIV-1 attachment and entry inhibitor. BMS-818251 binds to HIV-1 Env gp120, interferes with viral attachment and entry processes, and inhibits HIV-1 viral replication. BMS-818251 can be used in studies related to HIV-1 infection[1][2].
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BMS-818251 | 99.36% | BMS-818251 is a HIV-1 attachment and entry inhibitor. BMS-818251 binds to HIV-1 Env gp120, interferes with viral attachment and entry processes, and inhibits HIV-1 viral replication. BMS-818251 can be used in studies related to HIV-1 infection. | ||||||||||||||||||||
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- [1]. Lai Y-T, et al. Fostemsavir analog BMS-818251 has enhanced viral neutralization potency and similar escape mutation profile. Antimicrob Agents Chemother. 2025;69(10):e0191024. [Content Brief]
- [2]. Lai YT, et al. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun. 2019;10(1):47. Published 2019 Jan 3. [Content Brief]
Keywords
