2976498-55-0
2976498-55-0
Chemical Structure
PDEδ/NAMPT IN-1
- CAS No.: 2976498-55-0
- Formula:C26H30N4O4S
- Molecular Weight:494.61
SMILES: O=S(C1=CC=C(C=C1)NC(NCC2=CC=CN=C2)=O)(N(CC3=CC=C(C=C3)OC)C4CCCC4)=O
Biological Activity: PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer[1].
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PDEδ/NAMPT IN-1 | PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer. | |||||||||||||||||||||
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